Are Structurally Modified Galactomannan Derivatives Biologically Active?

Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities these polysaccharides have been extensively studied. derivatives obtained by sulfation, complexation, phosphorylation most studied biological properties galactomannans. shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, antileishmanial. Considering relevance studies, we aim to provide an overview studies that apply galactomannan modification or derivatization strategies improve their for applications biomedical area. We identified success modified galactomannans purposes. However, some found loss bioactivity original polysaccharide after its structures.